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A multicenter, open-label, comparative study of B-cell depletion therapy with Rituximab for systemic sclerosis-associated interstitial lung disease.

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Rituximab in diffuse cutaneous systemic sclerosis: an open-label clinical and histopatho-logical study.

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Effects and safety of rituximab in systemic sclerosis: an analysis from the European Scleroderma Trial and Research (EUSTAR) group. Combination therapy with rituximab and mycophenolate mofetil in systemic sclerosis.

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Clinical decision rule to predict the presence of interstitial lung disease in systemic sclerosis. Interstitial lung disease in systemic sclerosis: data from the spanish scleroderma study group. Severe restrictive lung disease in systemic sclerosis.

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Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database. October;69(10):1809–1815. [DOI] [PubMed] [Google Scholar] 35.Volkmann ER, Tashkin DP, Kuwana M, et al.

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Progression of Interstitial Lung Disease in Systemic Sclerosis: the Importance of Pneumoproteins Krebs von den Lungen 6 and CCL18. December;71(12):2059–2067. [DOI] [PMC free article] [PubMed] [Google Scholar] 36.Fischer A, Strek ME, Cottin V, et al. Proceedings of the American College of Rheumatology/Association of Physicians of Great Britain and Ireland connective tissue disease-associated interstitial lung disease summit: a multidisciplinary approach to address challenges and opportunities. February;71(2):182–195. [DOI] [PubMed] [Google Scholar] 37.Goldin JG, Kim GHJ, Tseng CH, et al. Longitudinal changes in quantitative interstitial lung disease on computed tomography after immunosuppression in the scleroderma lung study II. [DOI] [PMC free article] [PubMed] [Google Scholar] 38.Khanna D, Yan X, Tashkin DP, et al. Impact of oral cyclophosphamide on health-related quality of life in patients with active scleroderma lung disease: results from the scleroderma lung study.

Externe Links zu erwähnten Verbindungen

Baseline subject demographics and disease characteristics in a phase 3 study of safety and efficacy of lenabasum in diffuse cutaneous systemic sclerosis. An open-label, phase II study of the safety and tolerability of sildenafil 100mg blue pill pirfenidone in patients with scleroderma-associated interstitial lung disease: the LOTUSS trial. Nintedanib for systemic sclerosis-associated interstitial lung disease. [DOI] [PubMed] [Google Scholar]; • This was the largest RCT ever conducted in SSc and demonstrated that treatment with nintedanib slows the rate of decline of lung function in patients with SSc-ILD compared with placebo. Intravenous cyclophosphamide vs rituximab for the treatment of early diffuse scleroderma lung disease: open label, randomized, controlled trial. Effects of 1-year treatment with cyclophosphamide on outcomes at 2 years in scleroderma lung disease. [DOI] [PMC free article] [PubMed] [Google Scholar] 40.Volkmann ER, Tashkin DP, Sim M, et al. Cyclophosphamide for systemic sclerosis-related interstitial lung disease: a comparison of scleroderma lung study I and II.

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[DOI] [PMC free article] [PubMed] [Google Scholar] 41.Volkmann ER, Tashkin D. Roth M, LeClair H, et al.

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Mycophenolate mofetil and cyclophosphamide improve health-related quality of life in patients with systemic sclerosis who participated in SLS II.

Mode of Action TOURNES 100mg

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2.4. Pulmonary hypertension

Myeloablative autologous stem-cell transplantation for severe scleroderma. [DOI] [PMC free article] [PubMed] [Google Scholar]; • This was the second large, RCT to evaluate the safety and efficacy of HSCT in SSc and also demonstrated improved long-term mortality in dsSSc patients randomized to HSCT compared with CYC. Safety and efficacy of subcutaneous tocilizumab in systemic sclerosis: results from the open-label period of a phase II randomised controlled trial (faSScinate). [DOI] [PMC free article] [PubMed] [Google Scholar] 19.Khanna D, Spino C, Johnson S, et al. Abatacept in early diffuse cutaneous systemic sclerosis: results of a phase II investigator-initiated, multicenter, double-blind, randomized, placebo-controlled trial.

Areas covered:

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[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Peoples C, Medsger TA Jr., Lucas M, et al. Gender differences in systemic sclerosis: relationship to clinical features, serologic status and outcomes. [DOI] [PMC free article] [PubMed] [Google Scholar] February;34(1):1–15;v. [DOI] [PubMed] [Google Scholar] 6.Sierra-Sepulveda A, Esquinca-Gonzalez A, Benavides-Suarez SA, et al. Systemic sclerosis pathogenesis and emerging therapies, beyond the fibroblast.

Expert opinion:

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2.2. Interstitial lung disease

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All you need to know about TOURNES 100mg .

These therapeutic strategies primarily target individual organ manifestations of SSc. Immunosuppressants with potential disease-modifying effects continue to be important components of the therapeutic armamentarium for SSc. Patients with refractory disease may require combination therapy with anti-fibrotics and/or other agents. Defining mechanistically based SSc subgroups based on biological and clinical profiles will reduce heterogeneity in clinical trial cohorts and may enhance our ability to detect treatment effects. Preventing both the onset and progression of individual organ manifestation remains an important unmet clinical need in SSc.

Erektile Dysfunktion (ED)

Z McMahan is supported by the National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases via grant K23 AR071473, the Scleroderma Research Foundation and the Jerome L Greene Foundation. ER Volkmann is supported by National Institutes of Health/The National Heart, Lung, and Blood Institute via grant K23 HL150237-01 and the Rheumatology Research Foundation. One referee has received speaker’s fees, travel grants, research funding, or compensation for consultancies or board memberships from Abbvie, Actelion, Baxalta/Shire, Bristol-Myers Squibb, Boehringer Ingelheim, Celgene, Chugai, Genzyme, Gilead Biosciences, Hexal/Sandoz, Janssen-Cilag, Merck Sharp and Dohme, Novartis, Pfizer, Roche, Sanofi Pasteur and UCB Pharma. Peer reviewers on this manuscript have no other relevant financial relationships or otherwise to disclose. ER Volkmann has received grant support from Corbus Pharmaceuticals and Forbius, and consulting fees from Forbius and Boehringer Ingelheim.

2.3. Raynaud phenomenon

ZH McMahan has received salary support from Corbus Pharmaceuticals for her work as a subinvestigator on the Lenabasum study. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Papers of special note have been highlighted as either of interest (•) or of considerable interest (••) to readers. Treatment algorithms for systemic sclerosis according to experts. Emerging targets of disease-modifying therapy for systemic sclerosis.