Medicines in this group include avanafil (Stendra), sildenafil (Viagra, Revatio, and others), tadalafil (Cialis and others), and vardenafil (Levitra, Staxyn). If you take liquid tadalafil, shake the bottle well for 30 seconds before use.
| Condition | Explanation |
|---|---|
| Severe cardiovascular disease | Risk of cardiovascular events with sexual activity |
| Hypersensitivity | Allergy to Tadalafil or related compounds |
| Use with nitrates | Absolute contraindication due to severe hypotension |
| Retinitis Pigmentosa | Caution, potential for vision loss |
Use an accurate measuring device to measure your dose.
Possible Side- Effects
Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at or by calling 866-234-2345. While less common, the most serious side effects of tadalafil are described below, along with what to do if they happen. Tadalafil may cause allergic reactions, which can be serious.
Terms and Conditions
Stop taking tadalafil and get help right away if you have any of the following symptoms of a serious allergic reaction. Swelling of the face, lips, mouth, tongue, or throat Itching, skin rash, or pale red buy apcalis jelly bumps on the skin called hives Tadalafil may cause an unwanted erection that is persistent, painful, and that may occur without sexual arousal. Permanent damage to the penis may occur if priapism is not treated quickly. Stop taking tadalafil and get emergency help right away if you have any of the following symptoms of priapism. Erection lasting for more than 4 hours Erection that is unrelated to sexual stimulation If you feel faint or dizzy, lie down. A household spoon is not an accurate measuring device and may cause you to take the wrong dose.
- Apcalis 20 mg is a medication used to treat erectile dysfunction in men.
- It contains Tadalafil as the active ingredient.
- Apcalis 20 mg is typically taken 30 minutes before sexual activity.
- The effects of Apcalis 20 mg can last up to 36 hours.
- Do not take more than one dose of Apcalis 20 mg per day.
- Consult a doctor before using Apcalis 20 mg if you have underlying health conditions.
- Apcalis 20 mg may cause side effects like headache and dizziness.
- Avoid consuming alcohol while taking Apcalis 20 mg for safety.
- Apcalis 20 mg should be stored in a cool, dry place, away from children.
- It is important to follow prescribed dosages of Apcalis 20 mg for effectiveness.
Ask your pharmacist to recommend an appropriate measuring device. Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if tadalafil is right for you. In particular, make sure that you discuss any of the following.
- PDE5 is also found in other tissues, explaining some side effects.
- Back pain and muscle aches are thought to be related to PDE11 inhibition.
- These aches usually resolve within 12-48 hours after the dose.
- Over-the-counter pain relievers like acetaminophen may help.
- Avoid NSAIDs like ibuprofen if you have certain kidney or stomach issues.
- Flushing and stuffy nose are due to vasodilation in other vascular beds.
- Indigestion or acid reflux is a common but usually mild side effect.
- Taking the tablet with food may help reduce indigestion.
- If side effects are persistent or severe, contact your doctor.
- Do not stop or change your dose without medical consultation.
Tell your healthcare provider if you have any of the following. Heart problems, such as heart rhythm problems, chest pain, or heart failure Heart attack, stroke, or heart surgery within the past six months High blood pressure that is still too high despite taking medicines for it Peyronie's disease, or a penis with an abnormal curve or shape An erection lasting longer than four hours A blood disorder, such as sickle cell anemia, multiple myeloma, or leukemia An inherited eye disease called retinitis pigmentosa Vision loss, or a problem with the nerve between your eyes and brain (optic nerve) Health conditions or factors that raise the risk of optic nerve problems, such as diabetes, high cholesterol, smoking, being older than 50, or having a “crowded disc,” which is something an eye doctor may see in an eye exam Pulmonary veno-occlusive disease, a condition where blood vessels in the lungs are blocked It is not known if or how tadalafil could affect pregnancy or harm an unborn baby.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Apcalis SX Oral Jelly | 20mg | 17 + 4 Sachets | 95.52€ 90.97€ | |
| Apcalis SX Oral Jelly | 20mg | 30 + 5 Sachets | 141.84€ 135.09€ | |
| Apcalis SX Oral Jelly | 20mg | 50 + 6 Sachets | 146.39€ 139.42€ | |
| Priligy Generic Dapoxetine | 60mg | 10 Pills | 47.63€ 45.36€ | |
| Cialis Super Active | 20mg | 10 Pills | 55.64€ 52.99€ | |
| Priligy Generic Dapoxetine | 60mg | 180 + 10 Pills | 494.76€ 471.20€ | |
| Apcalis SX Oral Jelly | 20mg | 120 + 13 Sachets | 280.38€ 267.03€ | |
| Kamagra Gold | 50 mg | 120 + 6 Pills | 281.13€ 267.74€ | |
| Cialis Generic | 5mg | 10 Pills | 29.39€ 27.99€ | |
| Cialis Professional | 40mg | 30 Pills | 148.94€ 141.85€ | |
| Apcalis SX Oral Jelly | 20mg | 10 Sachets | 58.75€ 55.95€ | |
| Apcalis SX Oral Jelly | 20mg | 70 + 7 Sachets | 184.98€ 176.17€ | |
| Levitra Generic | 60mg | 60 + 4 Pills | 198.85€ 189.38€ | |
| Tadalista Super Active | 20mg | 30 + 6 Pills | 128.09€ 121.99€ | |
| Cialis Original | 20mg | 14 + 2 Pills | 95.75€ 91.19€ | |
| Kamagra 100 mg | 100 mg | 180 + 6 Pills | 436.79€ 415.99€ |
Tell your healthcare provider if you are or plan to become pregnant. Your healthcare provider will advise you if you should take tadalafil while you are pregnant or trying to get pregnant. It is not known if tadalafil passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider may recommend limiting or avoiding grapefruit while taking tadalafil. Grapefruit or grapefruit juice can raise tadalafil levels in your body, which can increase the risk of side effects.
Additional offers
See the Interactions section for more details. Do not take tadalafil unless it has been prescribed to you by a healthcare provider. Do not share tadalafil with other people, even if they have the same condition as you. Keep tadalafil out of the reach of children. Sexual activity can put extra strain on your heart, which may be unsafe for people with certain health problems, such as a recent heart attack.
Drug forms and administration
Talk to your healthcare provider to see if your heart is strong enough for sex. If you feel chest pain, dizziness, or nausea during sex, stop and contact your healthcare provider right away. Tadalafil does not protect against sexually transmitted infections, including HIV. Tadalafil belongs to a group of medicines, known as phosphodiesterase-5 (PDE-5) inhibitors, which are apcalis gel used to treat erectile dysfunction or pulmonary arterial hypertension. You should not take more than one PDE-5 inhibitor medicine. It is unknown if drinking alcohol will affect tadalafil. The risk of low blood pressure and dizziness may be increased if you drink alcohol while taking tadalafil. It is best to limit the amount of alcohol you drink while taking tadalafil. Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
| Parameter | Value | Notes |
|---|---|---|
| Absorption Time | 2 hours | Peak plasma concentration |
| Half-life | 17.5 hours | Duration of action |
| Bioavailability | Approximately 80% | After oral administration |
| Metabolism | Liver (via CYP3A4) | Mainly in liver |
| Excretion | Feces and urine | 61% feces, 36% urine |
In particular, make sure that you discuss if you are using any of the following before taking tadalafil. A nitrate, such as nitroglycerin (Nitro-Dur, Nitrostat, and others) or isosorbide, which is a medicine used for chest pain caused by a type of heart disease, or a street drug, such as amyl nitrite (“poppers”) A guanylate cyclase stimulator, such as riociguat (Adempas), which is a medicine used for high blood pressure in the lungs (pulmonary arterial hypertension), or vericiguat (Verquvo), which is a medicine used for a type of heart failure An alpha-blocker, such as alfuzosin (Uroxatral), doxazosin (Cardura), dutasteride, prazosin (Minipress), silodosin (Rapaflo), tamsulosin (Flomax), or terazosin (Hytrin), which is a medicine that may be used for high blood pressure and/or difficulty peeing due to an enlarged prostate A blood pressure medicine, such as amlodipine (Norvasc) or enalapril (Vasotec) Bosentan (Tracleer), which is a medicine used for pulmonary arterial hypertension A protease inhibitor, such as ritonavir (Norvir), which is a medicine commonly used to treat HIV Rifampin (Rifadin), which is a medicine commonly used to treat an infection called tuberculosis A medicine used for fungal infections, such as ketoconazole or itraconazole (Sporanox, Tolsura) Erythromycin (Ery-Tab and others) or clarithromycin (Biaxin), which is a medicine used for bacterial infections Any other medicine used for erectile dysfunction or pulmonary arterial hypertension Some other medicines may alter the blood levels of tadalafil.
All substitutes
This makes it easier to get and keep an erection. For pulmonary arterial hypertension, tadalafil relaxes the blood vessels in the lungs. This lowers blood pressure and reduces strain on the heart. For benign prostatic hyperplasia, tadalafil relaxes the muscles of the bladder and prostate, making it easier to urinate and reducing symptoms. Tadalafil should be stored at room temperature, between 68 F to 77 F (20 C to 25 C).
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It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. The most common side effects of tadalafil are listed below. The side effects may vary depending upon the condition being treated. Tell your healthcare provider if you have any of these side effects that bother you. Pain in your muscles, back, arms, or legs There may be other side effects of tadalafil that are not listed here. Tell your healthcare provider about all medicines that you take or have recently taken.
Therapeutic category and drug classification
Rest assured, we do not store your payment details — your financial information remains completely secure and private. Apcalis (Tadalafil 20mg) is used for the treatment of Erectile Dysfunction (ED) in adult men, a condition which implies difficulties in getting or keeping an erection. Apcalis can only be taken by adults aged 18 years and over. Do not take Apcalis if you also take medicines called nitrates often prescribed for chest pain. Tadalafil is a medicine that is commonly used for the following conditions.
Mild side effects
Erectile dysfunction, a condition where you have trouble getting or keeping an erection Pulmonary arterial hypertension, a condition where you have high blood pressure in the blood vessels that carry blood from your heart to your lungs Benign prostatic hyperplasia (BPH), a condition where the prostate gland has become enlarged Tadalafil may also be used for other conditions as determined by your healthcare provider. Tadalafil works by blocking the activity of an enzyme called phosphodiesterase 5 (PDE5). This enzyme usually stops some types of muscles from relaxing, including the muscles lining some types of blood vessels. By blocking PDE5, the muscles will relax and blood flow increases. For erectile dysfunction, it increases blood flow to the penis when aroused. This may not be a complete list of medicines that can interact with tadalafil. If you or someone else has used too much tadalafil, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.
7 tips for taking Cialis for maximum effect
Tell your healthcare provider right away if you have any of the following symptoms of low blood pressure. Tadalafil can cause mild, temporary vision changes such as seeing a blue tint, abnormal colors, blurry vision, or sensitivity to light. Though rare, some people have reported permanent vision loss. Stop taking tadalafil and get help right away if you have sudden vision loss in one or both eyes. Tadalafil may cause a sudden decrease or loss of hearing.
Cialis and other medications
Stop taking tadalafil and tell your healthcare provider right away if you experience hearing loss or have any of the following symptoms. People who are allergic to any of the following should not take tadalafil. Any of the ingredients in the specific product dispensed Your pharmacist can tell you all of the ingredients in the specific tadalafil products they stock. Tadalafil should not be taken while you are using certain other medicines. Before taking tadalafil, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. Do not take double or extra doses.

